Sulfuric Acid → HCID 68643692, compound

HRID 1157689Notes

Reaction equation

HRID 1157689 reaction equation
[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[C:5]([C:12]([O:14][CH3:15])=[O:13])[CH:6]=[CH:7][CH:8]=2)[CH2:3]1.S(=O)(=O)(O)O.[N+:21]([O-])([O-:23])=[O:22].[K+].[OH-].[Na+]>>[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[C:5]([C:12]([O:14][CH3:15])=[O:13])[CH:6]=[C:7]([N+:21]([O-:23])=[O:22])[CH:8]=2)[CH2:3]1

Participants

5

Reactant 4

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 24434Potassium NitrateHCID 68648873HCID 68648873, compound

Product 1

HCID 68643692HCID 68643692, compound

Conditions

Temperature
-7 °C

Procedure

A mixture of 1.04 g (5.0 mmol) 2-methyl-1,2,3,4-tetrahydro-8-methoxycarbonyl-isoquinoline and sulphuric acid is slowly combined at −7° C. with 0.57 g of potassium nitrate, then stirred for 15 min at −7° C. and for 1 h at ambient temperature. Then it is slowly poured onto ice water and made alkaline with NaOH. The crystals precipitated are filtered off and dried. A mixture of regioisomers is obtained.

Workup

  1. additionThen it is slowly poured onto ice water
  2. customThe crystals precipitated
  3. filtrationare filtered off
  4. customdried
  5. additionA mixture of regioisomers
  6. customis obtained

Sources & evidence

ORD record
ord-f78f8559910a47e79c816417e3409f16
Source dataset
uspto-grants-2010_10
Patent number
US07807693B2

Reaction notes

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