Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Potassium Nitrate | HCID 24434 | — |
| Reactant | HCID 68648873 | HCID 68648873 | — |
| Product | HCID 68643692 | HCID 68643692 | — |
Reaction Steps
A mixture of 1.04 g (5.0 mmol) 2-methyl-1,2,3,4-tetrahydro-8-methoxycarbonyl-isoquinoline and sulphuric acid is slowly combined at −7° C. with 0.57 g of potassium nitrate, then stirred for 15 min at −7° C. and for 1 h at ambient temperature. Then it is slowly poured onto ice water and made alkaline with NaOH. The crystals precipitated are filtered off and dried. A mixture of regioisomers is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07807693B2 |
|---|
| Source dataset | uspto-grants-2010_10 |
|---|
| ORD ID | ord-f78f8559910a47e79c816417e3409f16 |
|---|
| Source note | uspto-grants-2010_10 |
|---|
