反应详情

A mixture of 0.83 g of N-methyl-N-(4-nitrophenylmethyl)-2,2-dimethoxy-ethylamine and 3.0 ml trifluoromethanesulphonic acid is prepared in a dry ice/ethanol cooling bath, slowly brought to ambient temperature and stirred for 18 h. Then it is poured onto ice water, made alkaline with 2N NaOH, extracted 3× with EtOAc, the organic phases are dried with Na2SO4, concentrated and purified by repeated chromatography.

1. customis prepared in a dry ice/ethanol cooling bath
2. customslowly brought to ambient temperature
3. additionThen it is poured onto ice water
4. extractionextracted 3× with EtOAc
5. dry with materialthe organic phases are dried with Na2SO4
6. concentrationconcentrated
7. custompurified