反应详情

The crude allyl ether from step 3 (20.0 g) was dissolved in 2,4,6-trichlorobenzene (60 mL) and the solution was heated at reflux for 4 h. After being cooled to room temperature, the solution was directly loaded onto a column of silica gel and eluted sequentially with hexane and a 8:2 mixture of hexane and ethyl acetate to give 4-(4-chlorophenoxy)-2-(2-propenyl)phenol.

1. temperaturethe solution was heated
2. temperatureat reflux for 4 h
3. washeluted sequentially with hexane
4. additiona 8:2 mixture of hexane and ethyl acetate