N-methyl-2-pyrrolidone → HCID 178493790, compound

HRID 1157807Notes

Reaction equation

HRID 1157807 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[N:8][C:7]([O:10]C)=[C:6]2[NH:12][CH:13]=[CH:14][C:5]=12.CN1CCCC1=O>O>[OH:10][C:7]1[N:8]=[CH:9][C:4]([O:3][CH3:2])=[C:5]2[C:6]=1[NH:12][CH:13]=[CH:14]2

Participants

4

Reactant 2

HCID 13387N-methyl-2-pyrrolidoneHCID 573558204,7-Dimethoxy-1H-pyrrolo[2,3-c]pyridine hydrochloride

Product 1

HCID 178493790HCID 178493790, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
90 °C

Procedure

To 4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridine hydrochloride (50 g) taken in 2 L 3-necked round bottom flask, 250 ml N-methyl-2-pyrrolidinone was added followed by 8 ml of water, and was heated to 90° C. for about 4 hrs. The reaction mixture was cooled to room temperature, diluted with water (1 L) and the whole mixture was kept in cold room for about one hour. The resulting solid was collected by filtration, washed with cold water and dried in vacuum oven at 50° C. for 4 hrs to afford 7-hydroxyl-4-methoxy-6-azaindole as white solid.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with cold water
  4. customdried in vacuum oven at 50° C. for 4 hrs

Sources & evidence

ORD record
ord-1eadbe2c93e340f4b7927d33e5948706
Source dataset
uspto-grants-2010_10
Patent number
US07807676B2

Reaction notes

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