Cyclooctylamine → 1-Benzoyl-3-cyclooctylthiourea

HRID 1158065Notes

Reaction equation

HRID 1158065 reaction equation
[C:1]([N:9]=[C:10]=[S:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:12]1([NH2:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[C:1]([NH:9][C:10]([NH:20][CH:12]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[S:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2903CyclooctylamineHCID 68284Benzoyl isothiocyanate

Product 1

HCID 589299211-Benzoyl-3-cyclooctylthiourea

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Benzoyl isothiocyanate (7.40 mL, 54.0 mmol) was added to a solution of cyclooctanamine (6.25 g, 49.1 mmol) in 200 mL of chloroform. The mixture was stirred at ambient temperature overnight. The solvents were removed in vacuo to give the title compound as a viscous light yellowish oil. MS m/z: 291.0 (M+H)+.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-ddce96da417d473f8a14ca8d493a6b88
Source dataset
uspto-grants-2010_10
Patent number
US07807700B2

Reaction notes

Loading…