Sodium Hydroxide → HCID 86617896, compound

HRID 1158153Notes

Reaction equation

HRID 1158153 reaction equation
[C:1]([CH2:4][CH2:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:14]=[C:15]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([O:33]CC)=[O:32])=[CH:27][CH:26]=3)[CH:16]=[CH:17][C:18]=2[O:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24])=[CH:9][C:8]=1[C:36]([CH3:39])([CH3:38])[CH3:37])(=[O:3])[CH3:2].[OH-].[Na+]>O1CCCC1.O>[C:1]([CH2:4][CH2:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:14]=[C:15]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([OH:33])=[O:32])=[CH:27][CH:26]=3)[CH:16]=[CH:17][C:18]=2[O:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24])=[CH:9][C:8]=1[C:36]([CH3:39])([CH3:38])[CH3:37])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86617897HCID 86617897, compound

Product 1

HCID 86617896HCID 86617896, compoundYield 76.2%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

In a manner similar to that of Example 3, by reacting 270 mg of ethyl 4″-(acetylethylamino)-3″-tert-butyl-4′-(4-hydroxybutoxy)-[1,1′;3′,1″]terphenyl-4-carboxylate with 0.8 mL and then 0.4 mL of aqueous 1N sodium hydroxide solution in a mixture of 8 mL of tetrahydrofuran and 2 mL of water. 195 mg of 4″-(acetylethylamino)-3″-tert-butyl-4′-(4-hydroxybutoxy)-[1,1′;3′,1″]terphenyl-4-carboxylic acid are obtained in the form of a white solid (yield=95%, m.p.=75° C.).

Sources & evidence

ORD record
ord-553c31551e2543b792753d1a1b5dbcc2
Source dataset
uspto-grants-2010_10
Patent number
US07807708B2

Reaction notes

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