反应详情

0.288 g (3-methoxyphenyl)(2-(2,4,6-trimethoxybenzylthio)phenyl)methanol (K) (0.68 mmol) was treated with a solution of triethylsilane:TFA:DCM 0.3 ml:1 ml: 10 ml. The mixture was stirred overnight at ambient temperature before the addition of water. The mixture was extracted with DCM, brine, dried over magnesium sulfate and concentrated. Flash silica chromatography (hexane ethyl acetate 90:10) afforded 0.12 g product (0.52 mmol, 77% yield).

1. extractionThe mixture was extracted with DCM, brine
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated