HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-(3-Methoxybenzyl)benzenethiol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | (3-Methoxyphenyl)(2-(2,4,6-trimethoxybenzylthio)phenyl)methanol | HCID 68643652 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 2-(3-Methoxybenzyl)benzenethiol | HCID 68643620 | 77% |
Reaction Steps
0.288 g (3-methoxyphenyl)(2-(2,4,6-trimethoxybenzylthio)phenyl)methanol (K) (0.68 mmol) was treated with a solution of triethylsilane:TFA:DCM 0.3 ml:1 ml: 10 ml. The mixture was stirred overnight at ambient temperature before the addition of water. The mixture was extracted with DCM, brine, dried over magnesium sulfate and concentrated. Flash silica chromatography (hexane ethyl acetate 90:10) afforded 0.12 g product (0.52 mmol, 77% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807713B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-2d9b18eafa33450fbb9d807198ebb6cf |
| Source note | uspto-grants-2010_10 |