反应详情

Saturated hydrogen chloride in diethyl ether (20 mL) was added to a solution of (R)-1-(3-indolyl)-2-propylaminopentane (7.13 g) in diethyl ether under ice-cooling and stirring and then stirred at the same temperature for 10 minutes. The precipitated crystals were collected by filtration and washed three times with diethyl ether (10 mL). The resulting powder (7.70 g) was suspended in acetone (20 mL), and the suspension was stirred and refluxed for 10 minutes. The resulting yellow suspension was filtered, and the crystals were washed with acetone (5 mL three times) to give (R)-1-(3-indolyl)-2-propylaminopentane hydrochloride (4.43 g, 53% yield).

1. temperaturecooling
2. stirringstirred at the same temperature for 10 minutes
3. filtrationThe precipitated crystals were collected by filtration
4. washwashed three times with diethyl ether (10 mL)
5. stirringthe suspension was stirred
6. temperaturerefluxed for 10 minutes
7. filtrationThe resulting yellow suspension was filtered
8. washthe crystals were washed with acetone (5 mL three times)