Triethylamine → HCID 178526855, compound

HRID 1158302Notes

Reaction equation

HRID 1158302 reaction equation
[Cl:1][C:2]1[NH:3][C:4](I)=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1.C(N(CC)CC)C>C(O)C.[OH-].[Pd+2].[OH-].[C]>[Cl:1][C:2]1[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 178526897HCID 178526897, compound

Product 1

HCID 178526855HCID 178526855, compoundYield 83.5%

Reagents, catalysts & solvents 2

HCID 178502593HCID 178502593, compoundCatalystHCID 702EthanolSolvent

Procedure

2-Chloro-5-iodo-4-nitroimidazole (273 mg) was dissolved in ethanol (5 ml), then triethylamine (420 μl) and 20% palladium hydroxide-carbon (27 mg) were added, the reaction mixture was subjected to hydrogenation at a room temperature under normal pressure for 5 hours, there was obtained 2-chloro-4-nitroimidazole (123 mg, yield: 83.4%) as colorless solid product.

Sources & evidence

ORD record
ord-b68da1183d1f45eba3aaa5d28b83c174
Source dataset
uspto-grants-2010_10
Patent number
US07807843B2

Reaction notes

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