huagongshe.com
HRID1158350

反应详情

EQUATION

反应方程式

HRID 1158350 的结构方程式

REACTANTS

反应物

3
结构：CC#N
HCID6342

Acetonitrile

C2H3N

2 次

结构：CC#N.O
HCID18373917

Acetonitrile--water (1/1)

C2H5NO

结构：COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CO)C(C)C)ccc1OC
HCID59512299

未命名化合物

PRODUCTS

生成物

1
结构：COCCCOc1cc(C(=O)N(C[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2C=O)C(C)C)ccc1OC
HCID59512275

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

The title compound is prepared analogously as described for the title compound under E in Scheme 5 from (3S,4R)-3-hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester. TLC, Rf (CH2CO2/MeOH 95:5)=0.3. tR (HPLC, Macherey-Nagel Nucleosil C18 column, 10-100% CH3CN/H2O/5 min, 100% CH3CN/3 min, CH3CN and H2O containing 0.1% TFA, flow: 1.5 ml/min): 5.16 min.

WORKUP

后处理

  1. customThe title compound is prepared analogously
  2. custom5.16 min.