HRID1158354
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
The title compound is prepared in a similar manner as described for Example 9/reaction step F, from (3S*,4S*)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester (19.3 g, 56.1 mmol), isopropylamine (14.5 mL, 168 mmol) and NaBH(OAc)3 (29.7 g, 140 mmol) in 1,2-dichloroethane (0.5 L) as a yellowish oil. MS: 387.2 [M+H]+. tR (HPLC, C18 column, 5-100% CH3CN/H2O/6 min, 100% CH3CN/2 min, CH3CN and H2O containing 0.1% TFA, flow: 1 mL/min): 5.34 min.
WORKUP
后处理
- custom5.34 min.