Acetonitrile → 1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one

HRID 1158418Notes

Reaction equation

HRID 1158418 reaction equation
OC[C:3]([NH:6][C:7](=[O:9])[CH3:8])([CH3:5])C.N1CC[CH:13]([CH2:16][OH:17])[CH2:12][CH2:11]1.CC#N.O.CC#N>O>[OH:17][CH2:16][CH:13]1[CH2:5][CH2:3][N:6]([C:7](=[O:9])[CH3:8])[CH2:11][CH2:12]1

Participants

6

Reactant 4

HCID 6342AcetonitrileHCID 4207714-PiperidinemethanolHCID 519166N-(1-hydroxy-2-methylpropan-2-yl)acetamideHCID 18373917Acetonitrile--water (1/1)2×

Product 1

HCID 189349231-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared analogously as described for N-(2-hydroxy-1,1-dimethyl-ethyl)-acetamide from piperidin-4-yl-methanol. MS (LC-MS): [M+H]+=158.3. tR (HPLC, Waters Symmetry C18 column, 5-95% CH3CN/H2O/3.5 min, 95% CH3CN/H2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow: 0.6 mL/min): 0.39 min.

Workup

  1. custom0.39 min.

Sources & evidence

ORD record
ord-772d7d903336432db83eab4c3c1c8fd0
Source dataset
uspto-grants-2010_10
Patent number
US07807709B2

Reaction notes

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