HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 4-Piperidinemethanol | HCID 420771 | — |
| Reactant | N-(1-hydroxy-2-methylpropan-2-yl)acetamide | HCID 519166 | — |
| Reactant | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[4-(Hydroxymethyl)piperidin-1-yl]ethan-1-one | HCID 18934923 | — |
Reaction Steps
The title compound is prepared analogously as described for N-(2-hydroxy-1,1-dimethyl-ethyl)-acetamide from piperidin-4-yl-methanol. MS (LC-MS): [M+H]+=158.3. tR (HPLC, Waters Symmetry C18 column, 5-95% CH3CN/H2O/3.5 min, 95% CH3CN/H2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow: 0.6 mL/min): 0.39 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807709B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-772d7d903336432db83eab4c3c1c8fd0 |
| Source note | uspto-grants-2010_10 |