Benzyl(cyclopropylmethyl)amine → Cyclopropyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl chloride

HRID 1158425Notes

Reaction equation

HRID 1158425 reaction equation
[CH2:1]([N:8]([CH:12]1[CH2:14][CH2:13]1)[C:9]([Cl:11])=[O:10])[C:2]1[CH:7]=[CH:6]C=[CH:4][CH:3]=1.C1(NCC2CC[O:23]CC2)CC1.C(NCC1CC1)C1C=CC=CC=1>C(Cl)Cl.CO>[CH:12]1([N:8]([CH2:1][CH:2]2[CH2:7][CH2:6][O:23][CH2:4][CH2:3]2)[C:9]([Cl:11])=[O:10])[CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 518069Benzyl(cyclopropylmethyl)amineHCID 10608488Benzyl-cyclopropyl-carbamoyl chlorideHCID 61269370N-(oxan-4-ylmethyl)cyclopropanamine

Product 1

HCID 86622396Cyclopropyl-(tetrahydro-pyran-4-ylmethyl)-carbamoyl chloride

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared analogously as described for benzyl-cyclopropyl-carbamoyl chloride starting from cyclopropyl-(tetrahydro-pyran-4-ylmethyl)-amine (prepared analogously as described for benzyl-cyclopropylmethyl-amine). TLC, Rf (CH2Cl2/MeOH 95:5)=0.9.

Workup

  1. customprepared analogously

Sources & evidence

ORD record
ord-dd207a9a7e5f4cc686ba7ae4b1cf4015
Source dataset
uspto-grants-2010_10
Patent number
US07807709B2

Reaction notes

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