N-cyclopropyltetrahydro-2H-pyran-4-amine → Cyclopropyl(oxan-4-yl)carbamyl chloride

HRID 1158430Notes

Reaction equation

HRID 1158430 reaction equation
[CH:1]1([N:4]([CH2:8][CH:9]2[CH2:14]CCCO2)[C:5]([Cl:7])=[O:6])[CH2:3][CH2:2]1.C1(NC2CC[O:22][CH2:21][CH2:20]2)CC1>C(Cl)Cl.CO>[CH:1]1([N:4]([CH:8]2[CH2:9][CH2:14][O:22][CH2:21][CH2:20]2)[C:5]([Cl:7])=[O:6])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 6991952N-cyclopropyltetrahydro-2H-pyran-4-amineHCID 59512477HCID 59512477, compound

Product 1

HCID 54198639Cyclopropyl(oxan-4-yl)carbamyl chloride

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared analogously as described for cyclopropyl-(tetrahydro-pyran-2-ylmethyl)-carbamoyl chloride starting from commercially available cyclopropyl-(tetrahydro-pyran-4-yl)-amine. TLC, Rf (CH2Cl2/MeOH 95:5)=0.9.

Sources & evidence

ORD record
ord-f7fe6df52bbf4ae48daeb35ab8863681
Source dataset
uspto-grants-2010_10
Patent number
US07807709B2

Reaction notes

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