Acetonitrile → HCID 68618246, compound

HRID 1158494Notes

Reaction equation

HRID 1158494 reaction equation
C([SiH2][O:6][C:7](C)(C)[C@@H:8]1[CH2:12][NH:11][CH2:10][C@H:9]1[CH2:13][N:14]([CH2:24][CH:25]([CH3:27])[CH3:26])[S:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:17])=[O:16])(C)(C)C.CC#N.O.CC#N>O>[OH:6][CH2:7][C@@H:8]1[CH2:12][NH:11][CH2:10][C@H:9]1[CH2:13][N:14]([CH2:24][CH:25]([CH3:27])[CH3:26])[S:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:17])=[O:16]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 18373917Acetonitrile--water (1/1)2×HCID 131728368HCID 131728368, compound

Product 1

HCID 68618246HCID 68618246, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared as described above for Example 9/step H (Scheme 5) from N-[(3S*,4S*)-4-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-3-ylmethyl]-N-isobutyl-benzenesulfonamide. MS (LC-MS): 327.1 [M-Boc+H]+; tR (HPLC, Waters Symmetry C18 column, 20-95% CH3CN/H2O/3.5 min, 95% CH3CN/H2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow: 0.6 mL/min): 4.17 min.

Workup

  1. custom4.17 min.

Sources & evidence

ORD record
ord-ade3ecd5e70c49368df0c295dc20c982
Source dataset
uspto-grants-2010_10
Patent number
US07807709B2

Reaction notes

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