Trifluoroacetic acid → HCID 68679054, compound

HRID 1158518Notes

Reaction equation

HRID 1158518 reaction equation
C(OC(=O)[NH:7][CH:8]([C:16](=[O:27])[NH:17][CH:18]1[C:25]2[CH:24]=[CH:23][S:22][C:21]=2[CH2:20][CH:19]1[OH:26])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)(Cl)Cl>[NH2:7][CH:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:16]([NH:17][CH:18]1[C:25]2[CH:24]=[CH:23][S:22][C:21]=2[CH2:20][CH:19]1[OH:26])=[O:27]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68677751HCID 68677751, compound

Product 1

HCID 68679054HCID 68679054, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Compound 24a was dissolved in chloroform (400 mL) and TFA (100 mL) was added and the mixture was stirred for three hours at room temperature. The organic phase was washed two times with 15% ammonia solution (300 mL) and with brine. The organic phase was dried over sodium sulphate and evaporated. The product was purified by silica gel chromatography with DCM with three to ten percent methanol.

Workup

  1. washThe organic phase was washed two times with 15% ammonia solution (300 mL)
  2. dry with materialThe organic phase was dried over sodium sulphate
  3. customevaporated
  4. customThe product was purified by silica gel chromatography with DCM with three to ten percent methanol

Sources & evidence

ORD record
ord-abc2f84a5af24bab8b487056b811cca7
Source dataset
uspto-grants-2010_10
Patent number
US07807677B2

Reaction notes

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