反应详情

To a stirred solution of (3RS,4SR)-3-(3,4-dichloro-phenyl)-4-[(RS)-1-(4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidine (XV-B-1) 0.25 g (0.62 mmol) in CH2Cl2 (30 mL) at RT, 0.10 ml (0.74 mmol) of Et3N and 0.062 mL (0.74 mmol) of bromo-acetyl chloride were added. Stirring was continued over night and then concentrated under vacuo. The crude residue was dissolved in EtOAc, washed with H2O. The organic phase was dried over Na2SO4 and the product was purified by flash chromatography (SiO2, EtOAc) to yield the title product 0.275 g (85%) as a colorless oil.

1. waitwas continued over night
2. concentrationconcentrated under vacuo
3. dissolutionThe crude residue was dissolved in EtOAc
4. washwashed with H2O
5. dry with materialThe organic phase was dried over Na2SO4
6. customthe product was purified by flash chromatography (SiO2, EtOAc)