Hydrochloric Acid → (S)-1-allyl-3-amino-3,4-dihydrocarbostyril hydrochloride

HRID 11587Notes

Reaction equation

HRID 11587 reaction equation
[CH2:1]([N:4]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][C@H:7]([NH:15]C(OC(C)(C)C)=O)[C:5]1=[O:6])[CH:2]=[CH2:3].[ClH:23]>O1CCOCC1>[ClH:23].[CH2:1]([N:4]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][C@H:7]([NH2:15])[C:5]1=[O:6])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22868905(S)-1-allyl-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril

Product 1

HCID 69195858(S)-1-allyl-3-amino-3,4-dihydrocarbostyril hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(S)-1-allyl-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril (9.7 mg) was dissolved in 4 M hydrogen chloride in 1,4-dioxane solution (2 mL) at room temperature, and a white precipitate soon formed. After 30 min the solvent was evaporated under vacuum, and the residue was twice taken up in toluene (5 mL) and evaporated to provide (S)-1-allyl-3-amino-3,4-dihydrocarbostyril hydrochloride (7.6 mg).

Workup

  1. customa white precipitate soon formed
  2. customAfter 30 min the solvent was evaporated under vacuum
  3. customevaporated

Sources & evidence

ORD record
ord-5adcca477c254be6a192106fe55a0014
Source dataset
uspto-grants-2006_08
Patent number
US07098235B2

Reaction notes

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