Hydrochloric Acid → HCID 131728369, compound

HRID 1158773Notes

Reaction equation

[F:1][C:2]([F:36])([F:35])[C:3]1[N:34]=[C:6]2[CH2:7][N:8]([C@H:11]3[CH2:16][O:15][C@H:14]([C:17]4[CH:22]=[C:21]([F:23])[C:20]([F:24])=[CH:19][C:18]=4[F:25])[C@@H:13]([NH:26]C(=O)OC(C)(C)C)[CH2:12]3)[CH2:9][CH2:10][N:5]2[N:4]=1.[ClH:37]>>[ClH:37].[ClH:37].[F:36][C:2]([F:1])([F:35])[C:3]1[N:34]=[C:6]2[CH2:7][N:8]([C@H:11]3[CH2:16][O:15][C@H:14]([C:17]4[CH:22]=[C:21]([F:23])[C:20]([F:24])=[CH:19][C:18]=4[F:25])[C@@H:13]([NH2:26])[CH2:12]3)[CH2:9][CH2:10][N:5]2[N:4]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86633456HCID 86633456, compound

Product 1

HCID 131728369HCID 131728369, compound

Procedure

tert-Butyl [(2R,3S,5R)-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate from Step A was dissolved in a solution of hydrogen chloride (1 mL, 3N in ethyl acetate) and evaporated after two h to yield (2R,3S,5R)-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine, dihydrochloride salt. LC-MS 422.13 (M+1).

Workup

customevaporated after two h

Sources & evidence

ORD record: ord-2ef38e3db56d436b8ac3138737c643c8
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07812027B2

Reaction notes

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