Potassium Carbonate → 5-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

A solution of 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride (662 mg) in methanol (10 mL) was added 10% potassium carbonate aqueous solution at 0° F. and then stirred for 40 min at 0□. The mixture was concentrated under reduced pressure. The residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The compound was obtained as a pale brown powder (515 mg, quantitative).

1. concentrationThe mixture was concentrated under reduced pressure
2. customThe residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min
3. filtrationThe precipitate was filtered off
4. customdried in vacuo
5. customThe compound was obtained as a pale brown powder (515 mg, quantitative)

ORD record

ord-30ab975d9433465aa82428a1b34e4dd5

Source dataset

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07812014B2