反应详情

温度

23 °C

6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid diethyl ester (46 gram, 163 mmol) was dissolved in 200 ml THF. The solution was injected LAH (1M, THF) 300 ml at 23° C. Then it was stirred at 23° C. for 18 hrs. The reaction was quenched with 10 ml water and dried directly over sodium sulfate. Filter and concentrate yielded 29.3 gram (160 mmol, 98%) crude product.

1. customat 23° C
2. customThe reaction was quenched with 10 ml water
3. dry with materialdried directly over sodium sulfate
4. filtrationFilter
5. concentrationconcentrate