Ammonium Chloride → HCID 178425624, compound

HRID 1158907Notes

Reaction equation

HRID 1158907 reaction equation
[CH3:1][C:2]1([CH3:10])[CH2:7][CH2:6][C:5](OC)=[N:4][CH2:3]1.[Cl-:11].[NH4+:12]>C(O)C>[ClH:11].[CH3:1][C:2]1([CH3:10])[CH2:3][NH:4][C:5](=[NH:12])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 219413936-Methoxy-3,3-dimethyl-2,3,4,5-tetrahydropyridine

Product 1

HCID 178425624HCID 178425624, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The mixture of 3,3-dimethyl-6-methoxy-2,3,4,5-tetrahydropyridine (9.0 g, 64 mmol) and ammonium chloride (3.4 g, 64 mmol) in dry ethanol (160 mL) was heated to reflux for 2 h. The reaction mixture was then concentrated under reduced pressure and the titled compound was obtained as a white solid (9.9 g, 94.6%).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 2 h
  3. concentrationThe reaction mixture was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-2f0c9aec9ca847ee9650f575ea16b359
Source dataset
uspto-grants-2010_10
Patent number
US07812014B2

Reaction notes

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