反应详情

To the stirred solution of ethyl2,3-dihydropyrazolo[5,1-b][1,3]oxazole-6-carboxylate (5.47 g, 35 mmol) of in 100 ml of THF was added 1.05 g of lithium borohydride and 1.54 g of methanol. The solution was heated at 40 C for 2.5 hour. The reaction was quenched by 1N HCl, and adjusted to pH 1.3 and stirred at room temperature for 1 hour. The reaction mixture was adjusted pH to 8 with k2CO3. The reaction mixture was extracted with ethyl acetate. The organic layer was dried over MgSO4, and concentrated to an oil and column chromatographed to give 2.68 g of the desired product (65%).

1. temperatureThe solution was heated at 40 C for 2.5 hour
2. customThe reaction was quenched by 1N HCl
3. extractionThe reaction mixture was extracted with ethyl acetate
4. dry with materialThe organic layer was dried over MgSO4
5. concentrationconcentrated to an oil and column
6. customchromatographed