反应详情

The reductive amination of 3-(5-formyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile (27) (7.0 g, 26.3 mmol) and 4-aminobenzonitrile (10.2 g, 86.3 mmol), as described in Example 21, gave 4-{[5-(3-cyano-benzyloxy)-4,6-dimethyl-pyridin-3-ylmethyl]-amino}-benzonitrile (32) (4.1 g, 68% yield) as a colorless solid.