4-Cyanophenol → HCID 68644251, compound

HRID 1158955Notes

Reaction equation

HRID 1158955 reaction equation
[OH:1][CH2:2][C:3]1[C:4]([CH3:20])=[C:5]([O:10][CH2:11][C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[C:6]([CH3:9])=[N:7][CH:8]=1.[C:21]([C:23]1[CH:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1)#[N:22]>>[CH3:20][C:4]1[C:5]([O:10][CH2:11][C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)=[C:6]([CH3:9])[N:7]=[CH:8][C:3]=1[CH2:2][O:1][C:26]1[CH:27]=[CH:28][C:23]([C:21]#[N:22])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 130194-CyanophenolHCID 68644250HCID 68644250, compound

Product 1

HCID 68644251HCID 68644251, compoundYield 39.1%

Procedure

The coupling of 4-(5-hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile (22) (800 mg, 3.0 mmol) and 4-cyanophenol (715 mg, 6.0 mmol), as described in Example 9, gave 4-[4,6-dimethyl-5-(4-cyano-benzyloxy)-pyridin-3-ylmethoxy]-benzonitrile (67) (433 mg, 39% yield).

Sources & evidence

ORD record
ord-4c9fd5adae1e42f6a29dcc290b69d7d3
Source dataset
uspto-grants-2010_10
Patent number
US07812037B2

Reaction notes

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