反应详情

The coupling of 4-(5-hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile (22) (800 mg, 3.0 mmol) and 4-cyanophenol (715 mg, 6.0 mmol), as described in Example 9, gave 4-[4,6-dimethyl-5-(4-cyano-benzyloxy)-pyridin-3-ylmethoxy]-benzonitrile (67) (433 mg, 39% yield).