4-Desoxypyridoxine hydrochloride → HCID 58636777, compound

HRID 1158966Notes

Reaction equation

HRID 1158966 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]([CH3:10])[C:3]=1[OH:11].Cl.I[C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[C:17]#[N:18]>>[OH:9][CH2:8][C:7]1[C:2]([CH3:1])=[C:3]([O:11][C:14]2[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=2)[C:17]#[N:18])[C:4]([CH3:10])=[N:5][CH:6]=1

Participants

3

Reactant 2

HCID 674174-Desoxypyridoxine hydrochlorideHCID 1443413-Iodobenzonitrile

Product 1

HCID 58636777HCID 58636777, compoundYield 7.5%

Procedure

The coupling of 4-deoxypyridoxine hydrochloride (5.6 g, 29.5 mmol) and 3-iodobenzonitrile (10.0 g, 43.0 mmol), as described in Example 81, gave 3-(5-hydroxymethyl-2,4-dimethyl-pyridin-3-yloxy)-benzonitrile (93) (0.5 g, 7.5% yield).

Sources & evidence

ORD record
ord-127dd101f0604ff29d350c172ace2fc0
Source dataset
uspto-grants-2010_10
Patent number
US07812037B2

Reaction notes

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