HCID 58636831, compound → HCID 58636723, compound

HRID 1158988Notes

Reaction equation

HRID 1158988 reaction equation
[OH:1][CH2:2][C:3]1[C:4]([CH3:17])=[C:5]([O:13]C(=O)C)[C:6]([CH3:12])=[N:7][C:8]=1[CH2:9][CH2:10][CH3:11]>Cl>[OH:1][CH2:2][C:3]1[C:4]([CH3:17])=[C:5]([OH:13])[C:6]([CH3:12])=[N:7][C:8]=1[CH2:9][CH2:10][CH3:11]

Participants

3

Reactant 1

HCID 58636831HCID 58636831, compound

Product 1

HCID 58636723HCID 58636723, compoundYield 105.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of acetic acid 5-hydroxymethyl-2,4-dimethyl-6-propyl-pyridin-3-yl ester (176) (7.8 g, 32.9 mmol) in hydrochloric acid (100 mL, 1N) was refluxed for 90 minutes. The reaction mixture was evaporated to give 5-hydroxymethyl-2,4-dimethyl-6-propyl-pyridin-3-ol (177) (6.8 g, 97% yield).

Workup

  1. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-5b8ab1ddc01f43a98bf61c8da9777af4
Source dataset
uspto-grants-2010_10
Patent number
US07812037B2

Reaction notes

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