HCID 68644405, compound → HCID 68644634, compound

HRID 1158998Notes

Reaction equation

HRID 1158998 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:29])([CH2:23][N:24]1[CH:28]=[N:27][CH:26]=[N:25]1)[CH2:10][N:11]1[C:19]2[C:14](=[CH:15][C:16]([N+:20]([O-])=O)=[CH:17][CH:18]=2)[CH:13]=[N:12]1.[H][H]>CO.[Pd]>[NH2:20][C:16]1[CH:15]=[C:14]2[C:19](=[CH:18][CH:17]=1)[N:11]([CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[F:1])([OH:29])[CH2:23][N:24]1[CH:28]=[N:27][CH:26]=[N:25]1)[NH:12][CH2:13]2

Participants

5

Reactant 2

HCID 68644405HCID 68644405, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68644634HCID 68644634, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-(2,4-difluorophenyl)-1-(5-nitro-1H-indazol-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (3.57 g, 8.92 mmol) in methanol (50 ml) was added 5% palladium charcoal (Pd/C) (0.35 g) and hydrogen gas, followed by stirring for 12 hours. The reaction solution was filtered through celite. The filtrate was concentrated through vacuum evaporation to produce the title compound. (Yield 87%).

Workup

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationThe filtrate was concentrated through vacuum evaporation

Sources & evidence

ORD record
ord-dd968fdd5d114dc3ac5e984d57aa49d0
Source dataset
uspto-grants-2010_10
Patent number
US07812045B2

Reaction notes

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