HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68644405, compound → HCID 68644634, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68644405 | HCID 68644405 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68644634 | HCID 68644634 | 87% |
Reaction Steps
To a solution of 2-(2,4-difluorophenyl)-1-(5-nitro-1H-indazol-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (3.57 g, 8.92 mmol) in methanol (50 ml) was added 5% palladium charcoal (Pd/C) (0.35 g) and hydrogen gas, followed by stirring for 12 hours. The reaction solution was filtered through celite. The filtrate was concentrated through vacuum evaporation to produce the title compound. (Yield 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812045B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-dd968fdd5d114dc3ac5e984d57aa49d0 |
| Source note | uspto-grants-2010_10 |