Benzyl Chloride → HCID 68644646, compound

HRID 1158999Notes

Reaction equation

HRID 1158999 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:21]=1[F:27])([OH:19])[CH2:13][N:14]1[CH:18]=[N:17][CH:16]=[N:15]1)[NH:6][CH2:5]2.C(N(CC)C(C)C)(C)C.[CH2:37](Cl)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>C(#N)C>[CH2:37]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:21]=1[F:27])([OH:19])[CH2:13][N:14]1[CH:18]=[N:17][CH:16]=[N:15]1)[NH:6][CH2:5]2)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1

Participants

5

Reactant 3

HCID 7503Benzyl ChlorideHCID 81531DiisopropylethylamineHCID 68644634HCID 68644634, compound

Product 1

HCID 68644646HCID 68644646, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of (5-Amino-2H-indazol-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol (0.065 g, 0.17 mmol) in acetonitrile (1 ml) was slowly added N,N-Diisopropylethylamine (0.033 ml, 0.19 mmol) at 0° C. and the solution was stirred for 30 min in the same condition. Benzylchloride (0.024 g, 0.19 mmol) was added to the solution, which was then stirred at room temperature for 2 hours and concentrated using vacuum evaporation. The crude product was purified by chromatography on silica gel to give the title compound. (Yield 84%).

Workup

  1. customat 0° C.
  2. stirringwas then stirred at room temperature for 2 hours
  3. concentrationconcentrated
  4. customvacuum evaporation
  5. customThe crude product was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-4170c53a2bcf4ee395b465f1849712b7
Source dataset
uspto-grants-2010_10
Patent number
US07812045B2

Reaction notes

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