Hydrochloric Acid → HCID 11438993, compound

HRID 1159041Notes

Reaction equation

HRID 1159041 reaction equation
C(OC([N:8]1[CH2:28][CH2:27][N:11]2[C:12](=[O:26])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][C:16](/[CH:19]=[CH:20]\[CH3:21])=[CH:15][C:14]=3[C:22]([F:25])([F:24])[F:23])=O)(C)(C)C.[ClH:29]>CCOCC.O>[ClH:29].[CH:19](/[C:16]1[CH:17]=[C:18]2[C:13]([C:12](=[O:26])[N:11]3[CH2:27][CH2:28][NH:8][CH2:9][C@H:10]32)=[C:14]([C:22]([F:24])([F:25])[F:23])[CH:15]=1)=[CH:20]/[CH3:21]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68689588HCID 68689588, compound

Product 1

HCID 11438993HCID 11438993, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To a stirring solution of N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-(cis-1-propenyl)-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (40 mg, 0.1 mmol) in dry ether (2 mL) was added hydrochloric acid (1 mL). The reaction was stirred for 1 h and then conc. in vacuo to a white solid. The solid was dissolved in water and lyophilized to 24 mg of a white solid. MS (ESI) 297 (M−Cl).

Sources & evidence

ORD record
ord-094b0968c09e4893b8f09a14f51bfa38
Source dataset
uspto-grants-2010_10
Patent number
US07812024B2

Reaction notes

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