Hydrochloric Acid → HCID 11360044, compound

HRID 1159043Notes

Reaction equation

HRID 1159043 reaction equation
C(OC([N:8]1[CH2:29][CH2:28][N:11]2[C:12](=[O:27])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][C:16]([CH2:19][CH:20]([CH3:22])[CH3:21])=[CH:15][C:14]=3[C:23]([F:26])([F:25])[F:24])=O)(C)(C)C.[ClH:30]>CCOCC.O>[ClH:30].[CH3:21][CH:20]([CH3:22])[CH2:19][C:16]1[CH:17]=[C:18]2[C:13]([C:12](=[O:27])[N:11]3[CH2:28][CH2:29][NH:8][CH2:9][C@H:10]32)=[C:14]([C:23]([F:25])([F:24])[F:26])[CH:15]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68690573HCID 68690573, compound

Product 1

HCID 11360044HCID 11360044, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To a stirring solution of N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-(2-methylpropyl)-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (25 mg, 0.06 mmol) in dry ether (2 mL) was added hydrochloric acid (1 mL). The reaction was stirred for 1 h and then conc. in vacuo to a white solid. The solid was dissolved in water and lyophilized to 16 mg of a white solid. MS (ESI) 313 (M−Cl).

Sources & evidence

ORD record
ord-3057439139ff46148d57fc6d8ef92eef
Source dataset
uspto-grants-2010_10
Patent number
US07812024B2

Reaction notes

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