Hydrochloric Acid → HCID 11150989, compound

HRID 1159053Notes

Reaction equation

HRID 1159053 reaction equation
C(OC([N:8]1[CH2:26][CH2:25][N:11]2[C:12](=[O:24])[C:13]3[C:18]([C@@H:10]2[CH2:9]1)=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C:20]([F:23])([F:22])[F:21])=O)(C)(C)C.[ClH:27]>CCOCC.O>[ClH:27].[OH:19][C:16]1[CH:17]=[C:18]2[C:13]([C:12](=[O:24])[N:11]3[CH2:25][CH2:26][NH:8][CH2:9][C@H:10]32)=[C:14]([C:20]([F:23])([F:22])[F:21])[CH:15]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68689344HCID 68689344, compound

Product 1

HCID 11150989HCID 11150989, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

To a stirring solution of N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-hydroxy-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (14 mg, 0.04 mmol) in dry ether (2 mL) was added hydrochloric acid (1 mL). The reaction was stirred for 1 h and then conc. in vacuo to a white solid. The solid was dissolved in water and lyophilized to 10 mg of a white solid. MS (ESI) 273 (M−Cl).

Sources & evidence

ORD record
ord-a372acaa2c7647b48cbc841e6f0b9796
Source dataset
uspto-grants-2010_10
Patent number
US07812024B2

Reaction notes

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