2,2,2-Trifluoroethyl trifluoromethanesulfonate → 1-(2,2,2-Trifluoro-ethyl)-1H-indole-3-carboxylic acid thiazol-2-ylamide

HRID 1159138Notes

Reaction equation

HRID 1159138 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)=[O:8].O([CH2:26][C:27]([F:30])([F:29])[F:28])S(C(F)(F)F)(=O)=O>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:26][C:27]([F:30])([F:29])[F:28])[CH:10]=1)=[O:8]

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 17592646N-(1,3-thiazol-2-yl)-1H-indole-3-carboxamide

Product 1

HCID 595139331-(2,2,2-Trifluoro-ethyl)-1H-indole-3-carboxylic acid thiazol-2-ylamide

Procedure

The title compound was prepared using 1H-indole-3-carboxylic acid thiazol-2-ylamide and 2,2,2-trifluoroethyl triflate as R5X.

Sources & evidence

ORD record
ord-cb0eba50d9144ebaac0c0aa94cc4b2e5
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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