2-Aminothiazole → 406728-86-7

HRID 1159163Notes

Reaction equation

HRID 1159163 reaction equation
C(OC(C1NC=CC=1)=O)C.FC1C=CC(CBr)=CC=1.[F:20][C:21]1[CH:35]=[CH:34][C:24]([CH2:25][N:26]2[CH:30]=[CH:29][CH:28]=[C:27]2[C:31]([OH:33])=[O:32])=[CH:23][CH:22]=1.[NH2:36][C:37]1[S:38][CH:39]=[CH:40][N:41]=1>>[F:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:25][N:26]2[CH:30]=[CH:29][CH:28]=[C:27]2[C:31]([OH:33])=[O:32])=[CH:34][CH:35]=1.[S:38]1[CH:39]=[CH:40][N:41]=[C:37]1[NH:36][C:31]([C:27]1[N:26]([CH2:25][C:24]2[CH:23]=[CH:22][C:21]([F:20])=[CH:35][CH:34]=2)[CH:30]=[CH:29][CH:28]=1)=[O:33]

Participants

6

Reactant 4

HCID 21552-AminothiazoleHCID 680214-Fluorobenzyl bromideHCID 255670Ethyl 1H-pyrrole-2-carboxylateHCID 18627068406728-86-7

Product 2

HCID 18627068406728-86-7HCID 59514008HCID 59514008, compound

Procedure

1-(4-Fluorobenzyl)-pyrrole-2-carboxylic acid (1.18 g) was prepared from ethyl-pyrrole-2-carboxylate (1.39 g, 10.0 mmol) and 4-fluorobenzyl bromide (1.38 mL, 11.0 mmol) following the general procedures A and B. 1-(4-Fluorobenzyl)-pyrrole-2-carboxylic acid thiazol-2-ylamide (45 mg) was prepared from 1-(4-fluorobenzyl)-pyrrole-2-carboxylic acid (55 mg, 0.25 mmol) and 2-aminothiazole (25 mg, 0.25 mmol) following the general procedure F.

Sources & evidence

ORD record
ord-f1f130f73dfa427184a2a9444ef0d541
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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