2-Aminothiazole → HCID 59513927, compound

HRID 1159166Notes

Reaction equation

[CH:1]1([C:6]([C:8]2[CH:9]=[C:10]([C:17]([OH:19])=O)[N:11]([CH2:13][CH2:14][CH2:15][CH3:16])[CH:12]=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:20][C:21]1[S:22][CH:23]=[CH:24][N:25]=1>>[S:22]1[CH:23]=[CH:24][N:25]=[C:21]1[NH:20][C:17]([C:10]1[N:11]([CH2:13][CH2:14][CH2:15][CH3:16])[CH:12]=[C:8]([C:6]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:7])[CH:9]=1)=[O:19]

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 67093612HCID 67093612, compound

Product 1

HCID 59513927HCID 59513927, compoundYield 23.2%

Procedure

4-Cyclopentanecarbonyl-1-butyl-pyrrole-2-carboxylic acid (132 mg) was obtained following the hydrolysis of the ester intermediate via the general procedure E. 4-Cyclopentanecarbonyl-1-butyl-pyrrole-2-carboxylic acid thiazol-2-ylamide (40 mg) was prepared from 4-cyclopentanecarbonyl-1-butyl-pyrrole-2-carboxylic acid (132 mg, 0.5 mmol) and 2-aminothiazole (51 mg, 0.5 mmol) following the general procedure F.

Sources & evidence

ORD record: ord-adc52f57fc0341d5a31a4000a68bf47a
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07812043B2

Reaction notes

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