2-Aminothiazole → HCID 59513950, compound

HRID 1159168Notes

Reaction equation

HRID 1159168 reaction equation
C(OC(C1NN=C(CCC)C=1)=O)C.FC1C=CC(CBr)=CC=1.[F:23][C:24]1[CH:41]=[CH:40][C:27]([CH2:28][N:29]2[C:33]([C:34]([OH:36])=[O:35])=[CH:32][C:31]([CH2:37][CH2:38][CH3:39])=[N:30]2)=[CH:26][CH:25]=1.[NH2:42][C:43]1[S:44][CH:45]=[CH:46][N:47]=1>>[F:23][C:24]1[CH:25]=[CH:26][C:27]([CH2:28][N:29]2[C:33]([C:34]([OH:36])=[O:35])=[CH:32][C:31]([CH2:37][CH2:38][CH3:39])=[N:30]2)=[CH:40][CH:41]=1.[S:44]1[CH:45]=[CH:46][N:47]=[C:43]1[NH:42][C:34]([C:33]1[N:29]([CH2:28][C:27]2[CH:26]=[CH:25][C:24]([F:23])=[CH:41][CH:40]=2)[N:30]=[C:31]([CH2:37][CH2:38][CH3:39])[CH:32]=1)=[O:36]

Participants

6

Reactant 4

HCID 21552-AminothiazoleHCID 680214-Fluorobenzyl bromideHCID 67093945HCID 67093945, compoundHCID 178439317HCID 178439317, compound

Product 2

HCID 59513950HCID 59513950, compoundHCID 67093945HCID 67093945, compound

Procedure

2-(4-Fluorobenzyl)-5-propyl-2H-pyrazole-3-carboxylic acid (0.78 g) was prepared from 5-propyl-2H-pyrazole-3-carboxylic acid ethyl ester (0.91 g, 5.0 mmol) and 4-fluorobenzyl bromide (1.05 g, 5.5 mmol) following the general procedures D and E. 2-(4-Fluorobenzyl)-5-propyl-2H-pyrazole-3-carboxylic acid thiazol-2-ylamide (50 mg) was prepared from 2-(4-fluoro-benzyl)-5-propyl-2H-pyrazole-3-carboxylic acid (65 mg, 0.25 mmol) and 2-aminothiazole (25 mg, 0.25 mmol) following the general procedure F.

Sources & evidence

ORD record
ord-e68a06dbceb048d1a915ce20b16c2b2d
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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