2-Aminothiazole → HCID 59513965, compound

HRID 1159173Notes

Reaction equation

HRID 1159173 reaction equation
C(OC(C1NN=C(CCC)C=1)=O)C.ClC1C=C(C=CC=1Cl)CBr.[Cl:24][C:25]1[CH:26]=[C:27]([CH:40]=[CH:41][C:42]=1[Cl:43])[CH2:28][N:29]1[C:33]([C:34]([OH:36])=[O:35])=[CH:32][C:31]([CH2:37][CH2:38][CH3:39])=[N:30]1.[NH2:44][C:45]1[S:46][CH:47]=[CH:48][N:49]=1>>[Cl:24][C:25]1[CH:26]=[C:27]([CH:40]=[CH:41][C:42]=1[Cl:43])[CH2:28][N:29]1[C:33]([C:34]([OH:36])=[O:35])=[CH:32][C:31]([CH2:37][CH2:38][CH3:39])=[N:30]1.[S:46]1[CH:47]=[CH:48][N:49]=[C:45]1[NH:44][C:34]([C:33]1[N:29]([CH2:28][C:27]2[CH:40]=[CH:41][C:42]([Cl:43])=[C:25]([Cl:24])[CH:26]=2)[N:30]=[C:31]([CH2:37][CH2:38][CH3:39])[CH:32]=1)=[O:36]

Participants

6

Reactant 4

HCID 21552-AminothiazoleHCID 6397264-(Bromomethyl)-1,2-dichlorobenzeneHCID 67093751HCID 67093751, compoundHCID 178439317HCID 178439317, compound

Product 2

HCID 59513965HCID 59513965, compoundHCID 67093751HCID 67093751, compound

Procedure

2-(3,4-Dichlorobenzyl)-5-propyl-2H-pyrazole-3-carboxylic acid (0.84 g) was prepared from 5-propyl-2H-pyrazole-3-carboxylic acid ethyl ester (0.91 g, 5.0 mmol) and 3,4-dichlorobenzyl bromide (1.32 g, 5.5 mmol) following the general procedures D and E. 2-(3,4-dichlorobenzyl)-5-propyl-2H-pyrazole-3-carboxylic acid thiazol-2-ylamide (63 mg) was prepared from 2-(3,4-dichlorobenzyl)-5-propyl-2H-pyrazole-3-carboxylic acid (78 mg, 0.25 mmol) and 2-aminothiazole (25 mg, 0.25 mmol) following the general procedure F.

Sources & evidence

ORD record
ord-5725bc1b105340f19f4e85e693cecc50
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

Loading…