2-Methoxyethanol → HCID 24857250, compound

HRID 1159231Notes

Reaction equation

HRID 1159231 reaction equation
CO[C:3]([C:5]1[CH:10]=[C:9](Br)[C:8](=[O:12])[NH:7][CH:6]=1)=[O:4].[Cl:13][C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][CH:15]=1.[NH2:23][C@H:24]([CH2:29][OH:30])[C:25]([CH3:28])([CH3:27])[CH3:26].[CH3:31][O:32][CH2:33][CH2:34]O>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:9]2[C:8]([O:12][CH2:34][CH2:33][O:32][CH3:31])=[N:7][CH:6]=[C:5]([CH:10]=2)[C:3]([NH:23][C@H:24]([CH2:29][OH:30])[C:25]([CH3:28])([CH3:27])[CH3:26])=[O:4])=[CH:16][CH:15]=1

Participants

5

Reactant 4

HCID 80192-MethoxyethanolHCID 742994-Chlorophenylboronic acidHCID 2734079(2S)-2-Amino-3,3-dimethyl-1-butanolHCID 2764315Methyl 5-bromo-6-hydroxynicotinate

Product 1

HCID 24857250HCID 24857250, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 6, using 5-bromo-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid methyl ester, 2-methoxy-ethanol (commercially available), 4-chlorophenyl-boronic acid (commercially available) and L-tert-leucinol (commercially available) as starting materials. MS (ISP): 407.4 (MH+).

Workup

  1. customdescribed for the preparation of Example 6

Sources & evidence

ORD record
ord-b803125c5c8840fa89fbbf544ebe6a88
Source dataset
uspto-grants-2010_10
Patent number
US07812028B2

Reaction notes

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