3,4-Difluorobenzeneboronic acid → 6-Cyclopropylmethoxy-5-(3,4-difluoro-phenyl)-N-((trans)-2-hydroxy-cyclohexyl)-nicotinamide

HRID 1159234Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1159234
Br[C:2]1[C:3]([O:18][CH2:19][CH:20]2[CH2:22][CH2:21]2)=[N:4][CH:5]=[C:6]([CH:17]=1)[C:7]([NH:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]1[OH:16])=[O:8].[F:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][C:29]=1[F:30]>>[CH:20]1([CH2:19][O:18][C:3]2[C:2]([C:27]3[CH:26]=[CH:25][C:24]([F:23])=[C:29]([F:30])[CH:28]=3)=[CH:17][C:6]([C:7]([NH:9][C@@H:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[OH:16])=[O:8])=[CH:5][N:4]=2)[CH2:22][CH2:21]1

Komponenten

3

Edukt 2

HCID 27343373,4-Difluorobenzeneboronic acidHCID 675049715-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide

Produkt 1

HCID 119514806-Cyclopropylmethoxy-5-(3,4-difluoro-phenyl)-N-((trans)-2-hydroxy-cyclohexyl)-nicotinamide

Versuchsvorschrift

The title compound was synthesized in analogy to the Suzuki reaction procedure described for the preparation of Example 5a, from 5-Bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide and 3,4-difluorophenylboronic acid (commercially available). MS (ISP): 403.4 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-c909a71660fc4e42872152e9fb9b0774
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07812028B2

Notizen zur Reaktion

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