3,4-Difluorobenzeneboronic acid → 6-Cyclopropylmethoxy-5-(3,4-difluoro-phenyl)-N-((trans)-2-hydroxy-cyclohexyl)-nicotinamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3,4-Difluorobenzeneboronic acid	HCID 2734337	—
Edukt	5-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide	HCID 67504971	—
Produkt	6-Cyclopropylmethoxy-5-(3,4-difluoro-phenyl)-N-((trans)-2-hydroxy-cyclohexyl)-nicotinamide	HCID 11951480	—

Reaktionsschritte

The title compound was synthesized in analogy to the Suzuki reaction procedure described for the preparation of Example 5a, from 5-Bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide and 3,4-difluorophenylboronic acid (commercially available). MS (ISP): 403.4 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07812028B2
Quelldatensatz	uspto-grants-2010_10
ORD ID	ord-c909a71660fc4e42872152e9fb9b0774
Quellennotiz	uspto-grants-2010_10