Dibromomethane → Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate

HRID 1159238ノート

反応式

HRID 1159238 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8](N)=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:6]=1)=[O:4].C(ON=O)CC(C)C.[Br:27]CBr.C[Si](C)(C)Br>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([Br:27])=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[N:6]=1)=[O:4]

参加物

5

反応物 4

HCID 3024DibromomethaneHCID 8053Isoamyl NitriteHCID 76113BromotrimethylsilaneHCID 675046835-Amino-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid methyl ester

生成物 1

HCID 86619571Methyl 5-bromo-6-(4-chlorophenyl)pyrazine-2-carboxylate

実験手順

The title compound was synthesized in analogy to the procedure described for the preparation of Example 36b, using 5-amino-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid methyl ester as starting material and isoamylnitrite, dibromomethane and trimethylbromosilane as reagents to give the title compound which was used in the next step without further purification.

後処理

  1. customThe title compound was synthesized in analogy to the procedure
  2. customdescribed for the preparation of Example 36b

出典と根拠

ORDレコード
ord-facb351d80824956a4a49b2677ce551f
出典データセット
uspto-grants-2010_10
特許番号
US07812028B2

反応ノート

読み込み中…