4-Fluorophenylboronic acid → 5-Bromo-3-(4-fluorophenyl)pyrazin-2-amine

HRID 1159241Notes

Reaction equation

HRID 1159241 reaction equation
[NH2:1][C:2]1[C:7](Br)=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.[F:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[Br:9][C:5]1[N:6]=[C:7]([C:14]2[CH:15]=[CH:16][C:11]([F:10])=[CH:12][CH:13]=2)[C:2]([NH2:1])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 6200042-Amino-3,5-dibromopyrazine

Product 1

HCID 714639895-Bromo-3-(4-fluorophenyl)pyrazin-2-amine

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 19a using 2-amino-3,5-dibromopyrazine, and 4-fluorophenylboronic acid (commercially available) as starting materials to give the title compound as a white solid, MS (ISP) 268.1, 270.2 (M+H)+.

Workup

  1. customThe title compound was synthesized in analogy to the procedure
  2. customdescribed for the preparation of Example 19a

Sources & evidence

ORD record
ord-f3da15945c144fc7bd5868687ad80041
Source dataset
uspto-grants-2010_10
Patent number
US07812028B2

Reaction notes

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