Piperidine → HCID 24857164, compound

HRID 1159270Notes

Reaction equation

HRID 1159270 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[C:8](Br)[C:7](Cl)=[N:6][CH:5]=1.[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1.[NH2:29][CH2:30][C:31]([CH:34]1[CH2:36][CH2:35]1)([OH:33])[CH3:32]>>[CH:34]1([C:31]([OH:33])([CH3:32])[CH2:30][NH:29][C:3]([C:4]2[CH:9]=[C:8]([C:23]3[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=3)[C:7]([N:13]3[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]3)=[N:6][CH:5]=2)=[O:12])[CH2:36][CH2:35]1

Participants

5

Reactant 4

HCID 8082PiperidineHCID 742994-Chlorophenylboronic acidHCID 2764313Methyl 5-bromo-6-chloronicotinateHCID 211096921-Amino-2-cyclopropylpropan-2-ol

Product 1

HCID 24857164HCID 24857164, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 43, using 5-bromo-6-chloro-nicotinic acid methyl ester, piperidine (commercially available), 4-chlorophenyl-boronic acid (commercially available) and rac-1-amino-2-cyclopropyl-propan-2-ol (commercially available) as starting materials. MS (ISP): 414.4 (M+H+).

Workup

  1. customdescribed for the preparation of Example 43

Sources & evidence

ORD record
ord-732de32b0b594cdeb1d6490c93e7018f
Source dataset
uspto-grants-2010_10
Patent number
US07812028B2

Reaction notes

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