Water → HCID 86630392, compound

HRID 1159404Notes

Reaction equation

HRID 1159404 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C@@H:12]2[CH2:15][C@H:14]([OH:16])[CH2:13]2)[CH2:7][CH2:6]1)(=[O:4])=[O:3].C(N(CC)CC)C.[CH3:24][S:25](Cl)(=[O:27])=[O:26].O>C(Cl)Cl>[CH3:24][S:25]([O:16][CH:14]1[CH2:15][CH:12]([CH2:11][N:8]2[CH2:7][CH2:6][N:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH2:10][CH2:9]2)[CH2:13]1)(=[O:27])=[O:26]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 178504959HCID 178504959, compound

Product 1

HCID 86630392HCID 86630392, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Intermediate 37, cis-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}cyclobutanol and triethylamine were dissolved in CH2Cl2 (50 mL). MsCl was added dropwise at −20° C. under stirring in argon. The temperature was brought to ambient within 1 h. Water (100 mL) was added, and the layers were separated. The organic one was washed with water, brine, dried with Na2SO4, and evaporated, to give the title compound. This crude product was used for the next stage without additional purification.

Workup

  1. customthe layers were separated
  2. washThe organic one was washed with water, brine
  3. dry with materialdried with Na2SO4
  4. customevaporated

Sources & evidence

ORD record
ord-b9b3fbddd6b4469e83967041040f1aee
Source dataset
uspto-grants-2010_10
Patent number
US07812040B2

Reaction notes

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