Benzene, 1-chloro-3-isocyanato- → HCID 11710909, 화합물

HRID 1159453노트

반응식

HRID 1159453 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][CH:11]=[C:10]3[N:14]([CH3:18])[N:15]=[C:16]([NH2:17])[C:9]=23)=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([N:26]=[C:27]=[O:28])[CH:21]=1.FC1C=CC(C)=CC=1N=C=O>>[NH2:17][C:16]1[C:9]2[C:10](=[CH:11][N:12]=[CH:13][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:27]([NH:26][C:22]3[CH:23]=[CH:24][CH:25]=[C:20]([Cl:19])[CH:21]=3)=[O:28])=[CH:7][CH:6]=2)[N:14]([CH3:18])[N:15]=1

참가 물질

4

반응물 3

HCID 17968Benzene, 1-chloro-3-isocyanato-HCID 27333772-Fluoro-5-methylphenyl isocyanateHCID 686444744-(4-Amino-phenyl)-1-methyl-1H-pyrazolo[3,4-c]pyridin-3-ylamine

생성물 1

HCID 11710909HCID 11710909, 화합물

실험 절차

The title compound was prepared using the procedure described in Example 1E using the product from Example 6A and 1-chloro-3-isocyanato-benzene instead of the product from Example 1D and 1-fluoro-2-isocyanato-4-methyl-benzene. MS (ESI(+)) m/e 393 (M+H)+; 1H NMR (300 MHz, DMSO-D6) δ ppm 3.92 (s, 3H) 4.67 (s, 2H) 7.01-7.06 (m, 1H) 7.29-7.34 (m, 2H) 7.48 (d, J=8.48 Hz, 2H) 7.63 (d, J=8.48 Hz, 2H) 7.73 (s, 1H) 7.95 (s, 1H) 8.87 (s, 1 H) 8.97 (br.s, 2H).

출처 및 근거

ORD 기록
ord-1c709f36f0084ea5815e774e32e7d322
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812166B2

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