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HRID 1159457作成日：2026年10月25日

3-(Trifluoromethyl)phenyl isocyanate → N-[4-(3-amino-1-methyl-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]urea

https://huagongshe.com/reaction/1159457

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Trifluoromethyl)phenyl isocyanateHCID 9483—
反応物2-Fluoro-5-methylphenyl isocyanateHCID 2733377—
反応物4-(4-Amino-phenyl)-1-methyl-1H-pyrazolo[3,4-c]pyridin-3-ylamineHCID 68644474—
生成物N-[4-(3-amino-1-methyl-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]ureaHCID 11676233—

反応手順

The title compound was prepared using the procedure described in Example 1E using the product from Example 6A and 1-isocyanato-3-trifluoromethyl-benzene instead of the product from Example 1D and 1-fluoro-2-isocyanato-4-methyl-benzene. MS (ESI(+)) m/e 427 (M+H)+; 1H NMR (500 MHz, DMSO-D6) δ ppm 3.92 (s, 3H) 4.66 (s, 2H) 7.33 (d, J=7.49 Hz, 1H) 7.48 (d, J=8.73 Hz, 2H) 7.53 (t, J=7.95 Hz, 1H) 7.61 (d, J=9.05 Hz, 1H) 7.65 (d, J=8.73 Hz, 2H) 7.95 (s, 1H) 8.04 (s, 1H) 8.87 (s, 1H) 8.98 (s, 1H) 9.10 (s, 1H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07812166B2
出典データセットuspto-grants-2010_10
ORD IDord-2c05664a3e014f2f8824f27153493171
出典メモuspto-grants-2010_10